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John William Waterhouse, Jason and Medea, 1907, oil on canvas, 134 x 107 cm, private collection

Medea was a sorceress, and the wife of Jason, the captain of the Argonauts.  When her husband left her for another, she killed the other woman with a burning wedding dress, and then murdered her own children.  

She typically appears in scenes of her sorcery, killing her children, or in a chariot pulled by dragons.